Document Report Card
Basic Information
ID: ALA3397017
Journal: Bioorg Med Chem Lett
Title: Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat.
Authors: Tran TA, Shin YJ, Kramer B, Choi J, Zou N, Vallar P, Martens P, Boatman PD, Adams JW, Ramirez J, Shi Y, Morgan M, Unett DJ, Chang S, Shu HH, Tung SF, Semple G.
Abstract: The design and synthesis of two closely related series of prostacyclin receptor agonist compounds that showed excellent human IP receptor potency and efficacy is described. Compounds from this series showed in vivo activity after SC dosing in the monocrotaline model of PAH in rat.
CiteXplore: 25666818