Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives.
Basic Information
ID: ALA3397028
Journal: Bioorg Med Chem Lett
Title: Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives.
Authors: Konda S, Raparthi S, Bhaskar K, Munaganti RK, Guguloth V, Nagarapu L, Akkewar DM.
Abstract: A new series of benzoxazine-6-sulfonamide derivatives were synthesized in excellent yields and the resulting compounds were evaluated for their antimicrobial activities. All the synthesized compounds were assessed for their antibacterial and antifungal activities. Among them 1a, 1b, 1c, 1e, 1h, 2c, 2d, 2e, 2g, 2h, 2i, 2j, 2k and 2l showed low inhibitory concentration (MIC of 31.25 and 62.5 μg/mL) against Gram-positive bacteria, Gram-negative bacteria and fungi, which are comparable to the inhibitory effect of standard drugs.
CiteXplore: 25754493
DOI: 10.1016/j.bmcl.2015.01.026
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