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ID: ALA3399954

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.

Authors: Buzard DJ, Schrader TO, Zhu X, Lehmann J, Johnson B, Kasem M, Kim SH, Kawasaki A, Lopez L, Moody J, Han S, Gao Y, Edwards J, Barden J, Thatte J, Gatlin J, Jones RM.

Abstract: Modulators of S1P1 have proven utility for the treatment of autoimmune disease and efforts to identify new agents with improved safety and pharmacokinetic parameters are ongoing. Several new S1P1 chemotypes were designed and optimized for potency and oral bioavailability. These new agents are characterized by a 'tricyclic fused indole array' and are highly potent agonists of the S1P1 receptor.

CiteXplore: 25532755

DOI: 10.1016/j.bmcl.2014.11.089