Synthesis and activities towards resistant cancer cells of sulfone and sulfoxide griseofulvin derivatives.
Basic Information
ID: ALA3400116
Journal: Bioorg Med Chem Lett
Title: Synthesis and activities towards resistant cancer cells of sulfone and sulfoxide griseofulvin derivatives.
Authors: Liéby-Muller F, Heudré Le Baliner Q, Grisoni S, Fournier E, Guilbaud N, Marion F.
Abstract: Griseofulvin, an antifungal drug, has been shown in recent years to have anti-proliferative activities. We report here the synthesis of new analogs of griseofulvin, substituted in 2' by a sulfonyl group or in 3' by a sulfinyl or sulfonyl group. These compounds exhibit good anti-proliferative activities against SCC114 cells, an oral squamous carcinoma cell line showing pronounced centrosome amplification, and unexpected cytotoxic activities on HCC1937 cells, a triple negative breast cancer cell line resistant to microtubule inhibitors.
CiteXplore: 25872984
DOI: 10.1016/j.bmcl.2015.03.081
Patent ID: ┄