Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities.
Basic Information
ID: ALA3414547
Journal: Eur J Med Chem
Title: Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities.
Authors: Emami S, Ghanbarimasir Z.
Abstract: Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug discovery. Also, chroman-4-ones are important intermediates and interesting building blocks in organic synthesis and drug design. The structural diversity found in the chroman-4-one family led to their division into several categories including benzylidene-4-chromanones, flavanones (2-phenyl-4-chromanones), isoflavanones (3-phenyl-4-chromanones), spirochromanones, and C-4 modified chroman-4-ones such as hydrazones and oxime derivatives. This review addresses the most significant synthetic methods reported on 4-chromanone-derived compounds and consequently emphasizes on the biological relevance of such compounds.
CiteXplore: 25743215
DOI: 10.1016/j.ejmech.2015.02.048
Patent ID: ┄