Document Report Card

ID: ALA3421563

Journal: ACS Med Chem Lett

Title: Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.

Authors: O'Brien KT, Noto JG, Nichols-O'Neill L, Perez LJ.

Abstract: Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.

CiteXplore: 25699144

DOI: 10.1021/ml500459f