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ID: ALA3421620
Journal: Eur J Med Chem
Title: A facile synthesis of novel miconazole analogues and the evaluation of their antifungal activity.
Authors: Ramírez-Villalva A, González-Calderón D, González-Romero C, Morales-Rodríguez M, Jauregui-Rodríguez B, Cuevas-Yáñez E, Fuentes-Benítes A.
Abstract: Four novel miconazole analogues (8-11) were synthetized and evaluated for activity against four filamentous fungi (Mucor hiemalis, Aspergillus fumigatus, Trichosporon cutaneum, and Rhizopus oryzae) and eight species of Candida as yeast specimens. Compounds 9 and 10 showed very good activity when evaluated in yeast (MIC 0.112 and 0.163 μg/mL) compared to the reference compound, itraconazole (MIC 0.067 μg/mL). The best antifungal activity in filamentous strains was shown by compound 9. Hence compounds 9 and 10 represent new leads for further pharmacomodulation in this series.
CiteXplore: 25989345