Document Report Card

ID: ALA3576809

Journal: J Nat Prod

Title: Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.

Authors: Fu P, MacMillan JB.

Abstract: Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 μM.

CiteXplore: 25584783

DOI: 10.1021/np500929z