Document Report Card

ID: ALA3576828

Journal: J Nat Prod

Title: Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015.

Authors: Kim H, Yang I, Ryu SY, Won DH, Giri AG, Wang W, Choi H, Chin J, Hahn D, Kim E, Han C, Lee J, Nam SJ, Ho WK, Kang H.

Abstract: Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

CiteXplore: 25689430

DOI: 10.1021/np5007586