Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor.

ID: ALA3580568

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor.

Authors: Raeppel SL, Raeppel F, Therrien E.

Abstract: New carboxamide head group analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent and selective inhibitors of RON enzyme versus c-Met RTK were obtained.

CiteXplore: 25953155

DOI: 10.1016/j.bmcl.2015.04.056

Patent ID: ┄