Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
Basic Information
ID: ALA3585292
Journal: Bioorg Med Chem
Title: Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
Authors: Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M.
Abstract: In the course of our search for anti-dormant Mycobacterial substances, nybomycin (1) was re-discovered from the culture broth of a marine-derived Streptomyces sp. on the bioassay-guided separation. Compound 1 showed anti-microbial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG with the MIC of 1.0μg/mL under both actively growing aerobic conditions and dormancy inducing hypoxic conditions. Compound 1 is also effective to Mycobacterium tuberculosis including the clinically isolated strains. The mechanistic analysis indicated that 1 bound to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death.
CiteXplore: 25934225
DOI: 10.1016/j.bmc.2015.04.033
Patent ID: ┄