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ID: ALA3588824
Journal: J Nat Prod
Title: Bioactive Diterpenoids from the Leaves of Callicarpa macrophylla.
Authors: Xu J, Sun Y, Wang M, Ren Q, Li S, Wang H, Sun X, Jin DQ, Sun H, Ohizumi Y, Guo Y.
Abstract: A phytochemical investigation of the leaves of Callicarpa macrophylla led to the isolation of five new diterpenoids (1-5), macrophypenes A-E, and nine known analogues (6-14). The structures of 1-5 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compound 1 is a spiroditerpenoid with a novel skeleton, and compound 5 is a rare ent-abietane diterpenoid possessing a peroxide bridge. Compounds 1, 5-7, and 11-14 stimulate nerve growth factor mediated neurite outgrowth from PC12 cells.
CiteXplore: 26110519