Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents.

Basic Information

ID: ALA3596096

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents.

Authors: Suto Y, Nakajima-Shimada J, Yamagiwa N, Onizuka Y, Iwasaki G.

Abstract: Current chemotherapy drugs for Chagas' disease are insufficient due to their limited efficacy; however, anti-trypanosomal agents have recently shown promise. As such, synthetic intermediates of komaroviquinone were evaluated for anti-trypanosomal activity. Based on the results, a series of novel quinone derivatives were screened for anti-trypanosomal activity and mammalian cytotoxicity. Several quinone derivatives displayed higher antiprotozoal activity against Trypanosoma cruzi trypomastigotes than the reference drug benznidazole, without concomitant toxicity toward the host cell.

CiteXplore: 26037321

DOI: 10.1016/j.bmcl.2015.05.022

Patent ID: