Anti-plasmodial activity of bradykinin and analogs.

ID: ALA3600367

Journal: Bioorg Med Chem Lett

Title: Anti-plasmodial activity of bradykinin and analogs.

Authors: Silva AF, Alves FL, Pedron CN, Torres MD, Silva LS, Pinheiro AA, Miranda A, Oliveira VX.

Abstract: To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.

CiteXplore: 26077496

DOI: 10.1016/j.bmcl.2015.05.071

Patent ID: ┄