Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Basic Information
ID: ALA3600370
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Authors: Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, Bolzani Vda S, Graminha MA.
Abstract: Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi.
CiteXplore: 26055530
DOI: 10.1016/j.bmcl.2015.05.072
Patent ID: ┄