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ID: ALA3603743
Journal: Bioorg Med Chem
Title: Design, synthesis and biological evaluation of saccharin-based N-hydroxybenzamides as histone deacetylases (HDACs) inhibitors.
Authors: Fu H, Han L, Hou X, Dun Y, Wang L, Gong X, Fang H.
Abstract: We report the development of a novel series of saccharin-based N-hydroxybenzamides as histone deacetylases inhibitors. Among them, 6 j exhibited potent HDACs inhibitory activity against Hela nuclear extract. Further biological evaluation found 6 i showed similar antiproliferative activities in vitro compared with the approved SAHA.
CiteXplore: 26216016