Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.

Basic Information

ID: ALA3608217

Journal: Bioorg Med Chem Lett

Title: Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.

Authors: Renneberg D, Hubler F, Rey M, Hess P, Delahaye S, Gatfield J, Iglarz M, Hilpert K.

Abstract: Chemical evolution of mibefradil resulted in the identification of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers. A SAR study, in vitro and in vivo DMPK properties as well as the in vivo antihypertensive effect in rats are presented.

CiteXplore: 26231163

DOI: 10.1016/j.bmcl.2015.07.038

Patent ID: