Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Basic Information
ID: ALA3608217
Journal: Bioorg Med Chem Lett
Title: Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Authors: Renneberg D, Hubler F, Rey M, Hess P, Delahaye S, Gatfield J, Iglarz M, Hilpert K.
Abstract: Chemical evolution of mibefradil resulted in the identification of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers. A SAR study, in vitro and in vivo DMPK properties as well as the in vivo antihypertensive effect in rats are presented.
CiteXplore: 26231163
DOI: 10.1016/j.bmcl.2015.07.038
Patent ID: ┄
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