Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004.

ID: ALA3608230

Journal: Bioorg Med Chem Lett

Title: Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004.

Authors: Raeppel F, Raeppel SL, Therrien E.

Abstract: New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

CiteXplore: 26243370

DOI: 10.1016/j.bmcl.2015.07.080

Patent ID: ┄