Synergistic activation of quorum sensing in Vibrio harveyi.

ID: ALA3608305

Journal: Bioorg Med Chem Lett

Title: Synergistic activation of quorum sensing in Vibrio harveyi.

Authors: Mandabi A, Ganin H, Meijler MM.

Abstract: Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.

CiteXplore: 26248803

DOI: 10.1016/j.bmcl.2015.07.028

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