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ID: ALA3621060

Journal: Bioorg Med Chem Lett

Title: Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones.

Authors: Wang Y, Yan H, Ma C, Lu D.

Abstract: A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through a useful procedure starting from amino alcohol and pyrimido dichloride. All the products were characterized by (1)H NMR, (13)C NMR and HRMS spectral analysis and the stereochemical structure of key intermediate was also confirmed by a single crystal X-ray diffraction crystallographic analysis. Moreover, the anticancer activities were evaluated in vitro against human liver cancer Huh-7 cell line and human breast cancer A549 cell line.

CiteXplore: 26364944

DOI: 10.1016/j.bmcl.2015.09.002