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ID: ALA3621130

Journal: Bioorg Med Chem Lett

Title: Identification and characterization of β-sitosterol target proteins.

Authors: Lomenick B, Shi H, Huang J, Chen C.

Abstract: β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.

CiteXplore: 25804720

DOI: 10.1016/j.bmcl.2015.03.007