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ID: ALA3621186
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.
Authors: Zhang C, Li S, Ji L, Liu S, Li Z, Li S, Meng X.
Abstract: Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly.
CiteXplore: 26384290