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ID: ALA3632563

Journal: Bioorg Med Chem Lett

Title: Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.

Authors: Abzianidze VV, Prokofieva DS, Chisty LA, Bolshakova KP, Berestetskiy AO, Panikorovskii TL, Bogachenkov AS, Holder AA.

Abstract: Derivatives of phaeosphaeride A (PPA) were synthesised and characterised; then anti-cancer studies were carried out on the A549 cancer cell line. It was found that the acetyl derivative (compound 3) displayed comparable in vitro cytotoxicity to that of PPA (EC50=49±7 μM and EC50=46±5 μM, respectively), while chloroacetyl derivative 6 (EC50=33±7 μM) was found to have better efficacy towards the A549 cancer cell line.

CiteXplore: 26508550

DOI: 10.1016/j.bmcl.2015.10.048