Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound.

ID: ALA3632589

Journal: Bioorg Med Chem Lett

Title: Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound.

Authors: Kutsumura N, Nakajima R, Koyama Y, Miyata Y, Saitoh T, Yamamoto N, Iwata S, Fujii H, Nagase H.

Abstract: We evaluated antitrichomonal effects of δ opioid receptor (DOR) agonists and antagonists. Although all the agonists were inactive, the DOR antagonists BNTX (2a) and its derivatives 2b-d showed antitrichomonal activity with MIC of 20-40 μM. In addition, the development of a more effective synthetic method for the BNTX derivatives was achieved by using the Knoevenagel condensation.

CiteXplore: 26099536

DOI: 10.1016/j.bmcl.2015.06.002

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