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ID: ALA3739258
Journal: Bioorg Med Chem Lett
Title: Click-based synthesis of bromotyrosine alkaloid analogs as potential anti-biofilm leads for SAR studies.
Authors: Andjouh S, Blache Y.
Abstract: A library of triazole-based analogs of bromotyramine alkaloids such as verongamines, hemibastadins, pseudoceramine D and clavatidine E was designed in order to identify promising leads that may help in the control of bacterial biofilms. Twenty-three compounds were screened for their biofilm inhibitory activity against three strains of Gram-negative bacteria. SAR studies revealed that hemibastadins analogs were the most active compounds which act as inhibitors of biofilm development (EC50 8.8-29μM) without effect on bacterial growth even at high concentrations (100μM).
CiteXplore: 26564265