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ID: ALA3745644
Journal: Bioorg Med Chem Lett
Title: The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid.
Authors: Cui YM, Liu XL, Zhang WM, Lin HX, Ohwada T, Ido K, Sawada K.
Abstract: A series of N-acylaminoalkyloxime derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKα channels. The structure-activity relationship study revealed that a non-covalent interaction between the S atom of the 2-thiophene and the carbonyl O atom may contribute to conformation restriction for interaction with the ion channel. This research could guide the design and synthesis of novel abietane-based BK channel opener.
CiteXplore: 26707391