Azaphilones from an Acid Mine Extremophile Strain of a Pleurostomophora sp.
Basic Information
ID: ALA3758076
Journal: J Nat Prod
Title: Azaphilones from an Acid Mine Extremophile Strain of a Pleurostomophora sp.
Authors: Stierle AA, Stierle DB, Girtsman T, Mou TC, Antczak C, Djaballah H.
Abstract: An extremophilic fungus identified as a Pleurostomophora sp. was isolated from the Berkeley Pit, an acid mine waste lake. When grown in liquid culture, the fungus produced berkchaetoazaphilones A-C (1, 2, and 5), the red pigment berkchaetorubramine (6), and the known compound 4-(hydroxymethyl)quinoline. These compounds were evaluated as inhibitors of matrix metalloproteinase-3, caspase-1, and proinflammatory cytokine production in induced THP-1 cells. Berkchaetoazaphilone B (2) inhibited IL-1β, TNFα, and IL-6 production in the induced inflammasome assay and was cytotoxic toward human retinoblastoma cell line Y79 (IC50 = 1.1 μM), leukemia cell lines CCRF-CEM and SR, and the melanoma cell line LOX IMVI (IC50 = 10 μM).
CiteXplore: 26641525
DOI: 10.1021/acs.jnatprod.5b00519
Patent ID: ┄