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ID: ALA3763044

Journal: Bioorg Med Chem Lett

Title: Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors.

Authors: Stranix BR, Wu JJ, Milot G, Beaulieu F, Bouchard JE, Gouveia K, Forte A, Garde S, Wang Z, Mouscadet JF, Delelis O, Xiao Y.

Abstract: A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.

CiteXplore: 26826732

DOI: 10.1016/j.bmcl.2016.01.028