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ID: ALA3763151
Journal: J Nat Prod
Title: Antinociceptive Grayanoids from the Roots of Rhododendron molle.
Authors: Li Y, Liu YB, Zhang JJ, Liu Y, Ma SG, Qu J, Lv HN, Yu SS.
Abstract: Nine new grayanoids (1-9), together with 11 known compounds, were isolated from the roots of Rhododendron molle. The structures of the new compounds (1-9) were determined on the basis of spectroscopic analysis, including HRESIMS, and 1D and 2D NMR data. Compounds 4, 6, 12, and 14-20 showed significant antinociceptive activities in an acetic acid-induced writhing test. In particular, 14 and 15 were found to be more potent than morphine for both acute and inflammatory pain models and 100-fold more potent than gabapentin in a diabetic neuropathic pain model.
CiteXplore: 26599832