Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis.
Basic Information
ID: ALA3774353
Journal: Bioorg Med Chem
Title: Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis.
Authors: Browne EC, Parakh S, Duncan LF, Langford SJ, Atkin JD, Abbott BM.
Abstract: Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1, and a series of peptide nucleic acids conjugated to synthetic lipophilic vitamin analogs including a recently prepared menadione (vitamin K) analog. Reduction of both mutant superoxide dismutase 1 inclusion formation and endoplasmic reticulum stress, two of the key cellular pathological hallmarks in amyotrophic lateral sclerosis, by two of the prepared PNA oligomers is reported for the first time.
CiteXplore: 26935939
DOI: 10.1016/j.bmc.2016.02.022
Patent ID: ┄