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ID: ALA3774363
Journal: ACS Med Chem Lett
Title: Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase.
Authors: Wills VS, Allen C, Holstein SA, Wiemer DF.
Abstract: Studies of triazole bisphosphonates have resulted in identification of a potent inhibitor of geranylgeranyl diphosphate synthase (IC50 = 45 nM) with very good selectivity for this enzyme over farnesyl diphosphate synthase (IC50 = 28 μM). This compound also potently disrupts geranylgeranylation and induces cytotoxicity in human myeloma cells at submicromolar levels, suggesting that it may serve as a lead compound for treatment of malignancies characterized by excessive protein secretion.
CiteXplore: 26713103