Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.
Basic Information
ID: ALA3779788
Journal: Bioorg Med Chem Lett
Title: Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.
Authors: Subhedar DD, Shaikh MH, Arkile MA, Yeware A, Sarkar D, Shingate BB.
Abstract: We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116.
CiteXplore: 26927426
DOI: 10.1016/j.bmcl.2016.02.056
Patent ID: ┄