Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.

Basic Information

ID: ALA3785014

Journal: J Med Chem

Title: A Binding Site on IL-17A for Inhibitory Macrocycles Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry.

Authors: Espada A, Broughton H, Jones S, Chalmers MJ, Dodge JA.

Abstract: Computational assessment of the IL-17A structure identified two distinct binding pockets, the β-hairpin pocket and the α-helix pocket. The β-hairpin pocket was hypothesized to be the site of binding for peptide macrocycles. Support for this hypothesis was obtained using HDX-MS which revealed protection to exchange only within the β-hairpin pocket. This data represents the first direct structural evidence of a small molecule binding site on IL-17A that functions to disrupt the interaction with its receptor.

CiteXplore: 26854023

DOI: 10.1021/acs.jmedchem.5b01693

Patent ID: