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ID: ALA3792323

Journal: Bioorg Med Chem Lett

Title: Piperidine derivatives as nonprostanoid IP receptor agonists.

Authors: Hayashi R, Sakagami H, Koiwa M, Ito H, Miyamoto M, Isogaya M.

Abstract: The discovery of a new class of nonprostanoid prostaglandin I2 receptor (IP receptor) agonists is reported. Among them, the unique piperidine derivative 31b (2-((1-(2-(N-(4-tolyl)benzamido)ethyl)piperidin-4-yl)oxy)acetic acid) was a good IP receptor agonist and was 50-fold more selective for the human IP receptor than for other human prostanoid receptors. This compound showed good pharmacokinetic properties in dog.

CiteXplore: 26996371

DOI: 10.1016/j.bmcl.2016.03.009