Strategies for improving the solubility and metabolic stability of griseofulvin analogues.
Basic Information
ID: ALA3792375
Journal: Eur J Med Chem
Title: Strategies for improving the solubility and metabolic stability of griseofulvin analogues.
Authors: Petersen AB, Konotop G, Hanafiah NHM, Hammershøj P, Raab MS, Krämer A, Clausen MH.
Abstract: We report two types of modifications to the natural product griseofulvin as strategies to improve solubility and metabolic stability: the conversion of aryl methyl ethers into aryl difluoromethyl ethers at metabolic hotspots and the conversion of the C-ring ketone into polar oximes. The syntheses of the analogues are described together with their solubility, metabolic half-life in vitro and antiproliferative effect in two cancer cell lines. We conclude that on balance, the formation of polar oximes is the most promising strategy for improving the properties of the analogues.
CiteXplore: 27061984
DOI: 10.1016/j.ejmech.2016.03.071
Patent ID: ┄