Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

ID: ALA3797031

Journal: Bioorg Med Chem Lett

Title: Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

Authors: Tian Y, Ma Y, Gibeau CR, Lahue BR, Shipps GW, Strickland C, Bogen SL.

Abstract: Led by the structural information of the screening hit with mDM2 protein, a structure modification of Leu26 moiety of the novel p53-hDM2 inhibitors was conducted. A structure-activity relationship study of 4-substituted piperidines revealed compound 20t with good potencies and excellent CYP450 profiles.

CiteXplore: 27080185

DOI: 10.1016/j.bmcl.2016.03.078

Patent ID: ┄