Repurposing strategies for tropical disease drug discovery.
Basic Information
ID: ALA3797071
Journal: Bioorg Med Chem Lett
Title: Repurposing strategies for tropical disease drug discovery.
Authors: Klug DM, Gelb MH, Pollastri MP.
Abstract: Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are disproportionately low compared to their impact on human health worldwide. Therefore, pragmatic methods for launching new drug discovery programs have emerged that repurpose existing chemical matter as new drugs or new starting points for optimization. In this Digest we describe applications of different repurposing approaches for NTDs, and provide a means by which these approaches may be differentiated from each other. These include drug repurposing, target repurposing, target class repurposing, and lead repurposing.
CiteXplore: 27080183
DOI: 10.1016/j.bmcl.2016.03.103
Patent ID: ┄