Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates.

ID: ALA3797123

Journal: Bioorg Med Chem Lett

Title: Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates.

Authors: Heller L, Perl V, Wiemann J, Al-Harrasi A, Csuk R.

Abstract: While 3-O-acetylated betulin derivatives carrying a carbamate moiety at position C-28 are of rather low cytotoxicity for human tumor cell lines, the corresponding C-3 amino(oxo) acetates show good cytotoxicity. For example, an EC50 as low as 2.0μM was found for (3β) 28-{[(hexylamino)carbonyl]oxy}lup-20(29)-en-3-yl amino(oxo)acetate (16) employing the ovarian cancer cell line A2780.

CiteXplore: 27142753

DOI: 10.1016/j.bmcl.2016.04.055

Patent ID: ┄