Document Report Card
Basic Information
ID: ALA3813597
Journal: Bioorg Med Chem Lett
Title: Discovery of indole inhibitors of chemokine receptor 9 (CCR9).
Authors: Pandya BA, Baber C, Chan A, Chamberlain B, Chandonnet H, Goss J, Hopper T, Lippa B, Poutsiaka K, Romero J, Stucka S, Varoglu M, Zhang J, Zhang X.
Abstract: Irritable bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are serious chronic diseases affecting millions of patients worldwide. Studies of human chemokine biology has suggested C-C chemokine receptor 9 (CCR9) may be a key mediator of pro-inflammatory signaling. Discovery of agents that inhibit CCR9 may lead to new therapies for CD and UC patients. Herein we describe the evolution of a high content screening hit (1) into potent inhibitors of CCR9, such as azaindole 12.
CiteXplore: 27256913