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ID: ALA3817810
Journal: Bioorg Med Chem Lett
Title: Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis.
Authors: Li MC, Sun WS, Cheng W, Liu D, Liang H, Zhang QY, Lin WH.
Abstract: Four new minor brominated indole related alkaloids (one indoles, 1, one 1,3-dihydro-indole-2-one, 2, one carbazole, 3, and one 2-carbonylamino-benzoate, 4) were isolated and identified from Laurencia similis by extensive chromatographic and spectrometric methods. Among them, 1 and 2 were the first example of naturally occurring indole with 3-benzyl group and 1,3-dihydro-indole-2-one with 2-isopropylidene group, respectively, whereas 3 and 4 were the first carbazole alkaloids and 2-carbonylamino-benzoate, respectively, isolated from the genus Laurencia. Moreover, 1 showed the most potent antibacterial activity against seven bacterial strains with MIC values ranging from 2 to 8μg/mL.
CiteXplore: 27318539