Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
Basic Information
ID: ALA3822374
Journal: Bioorg Med Chem Lett
Title: Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata.
Authors: Li YJ, Xu CT, Lin DD, Qin JK, Ye GJ, Deng QH.
Abstract: A new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (compound 1), together with seven known polyphenolic compounds, were isolated from the stem of Cissus pteroclada Hayata. The structures of the 8 compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Moreover, the in vitro anti-inflammatory effects of compounds (1-8) in LPS-stimulated murine macrophage RAW 264.7 cells were also investigated. Our results revealed that compound 1 inhibited the production of pro-inflammatory mediators NO and PGE2 and the expression of NF-κB, TNF-α, IL-1β, iNOS and COX-2.
CiteXplore: 27374242
DOI: 10.1016/j.bmcl.2016.06.054
Patent ID: ┄