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ID: ALA3826953
Journal: J Med Chem
Title: Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
Authors: Castagna D, Budd DC, Macdonald SJ, Jamieson C, Watson AJ.
Abstract: The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is implicated in a variety of human disease states including angiogenesis, autoimmune diseases, cancer, fibrotic diseases, inflammation, neurodegeneration, and neuropathic pain, among others. As a result, ATX-LPA has become of significant interest within both the industrial and the academic communities. This review aims to provide a concise overview of the development of novel ATX inhibitors, including the disclosure of the first ATX clinical trial data.
CiteXplore: 26745766