Document Report Card

ID: ALA3861950

Journal: Medchemcomm

Title: Design, synthesis and evaluation of novel ¹⁹F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

Authors: Li Y, Xia G, Guo Q, Wu L, Chen S, Yang Z, Wang W, Zhang ZY, Zhou X, Jiang ZX.

Abstract: Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatases (PTPs)-targeted drug discovery and imaging-guided PTP research with fluorine, several highly potent and ¹⁹F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

CiteXplore: 27529021

DOI: 10.1039/C6MD00277C