Document Report Card

Basic Information

ID: ALA3864123

Journal: Bioorg Med Chem

Title: Drug discovery strategies to outer membrane targets in Gram-negative pathogens.

Authors: Brown DG.

Abstract: This review will cover selected recent examples of drug discovery strategies which target the outer membrane (OM) of Gram-negative bacteria either by disruption of outer membrane function or by inhibition of essential gene products necessary for outer membrane assembly. Significant advances in pathway elucidation, structural biology and molecular inhibitor designs have created new opportunities for drug discovery within this target-class space.

CiteXplore: 27178386

DOI: 10.1016/j.bmc.2016.05.004