Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
Basic Information
ID: ALA3864129
Journal: J Nat Prod
Title: Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
Authors: Liu H, Lohith K, Rosario M, Pulliam TH, O'Connor RD, Bell LJ, Bewley CA.
Abstract: Antibacterial-guided fractionation of the Dictyoceratid sponges Lamellodysidea sp. and two samples of Dysidea granulosa yielded 14 polybrominated, diphenyl ethers including one new methoxy-containing compound (8). Their structures were elucidated by interpretation of spectroscopic data of the natural product and their methoxy derivatives. Most of the compounds showed strong antimicrobial activity with low- to sub-microgram mL(-1) minimum inhibitory concentrations against drug-susceptible and drug-resistant strains of Staphylococcus aureus and Enterococcus faecium, and two compounds inhibited Escherichia coli in a structure-dependent manner.
CiteXplore: 27399938
DOI: 10.1021/acs.jnatprod.6b00229
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