Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan.
Basic Information
ID: ALA3867445
Journal: J Nat Prod
Title: Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan.
Authors: Chen JY, Huang CY, Lin YS, Hwang TL, Wang WL, Chiou SF, Sheu JH.
Abstract: Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward elastase release generation at 10 μM.
CiteXplore: 27536968
DOI: 10.1021/acs.jnatprod.6b00452
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