Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius.
Basic Information
ID: ALA3868628
Journal: Bioorg Med Chem Lett
Title: Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius.
Authors: Jin Q, Lee JW, Jang H, Choi JE, Kim HS, Lee D, Hong JT, Lee MK, Hwang BY.
Abstract: Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3-8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (1H and 13C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.
CiteXplore: 27865705
DOI: 10.1016/j.bmcl.2016.10.017
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