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ID: ALA3994643
Journal: Bioorg Med Chem Lett
Title: Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives.
Authors: Xiao C, Tian Y, Lei M, Chen F, Gan X, Yao X, Shen X, Chen J, Hu L.
Abstract: It is demonstrated that natural product vindoline can enhance the glucose-stimulated insulin secretion (GSIS) in MIN6 cells with the EC50 value of 50.2μM. In order to improve the activities, a series of vindoline derivatives are synthesized and evaluated in MIN6 cells. Compounds 4, 8, 17 and 24 show about 4.5 times more effective stimulation insulin secretion ability (EC50: 10.4, 14.2, 11.0 and 12.7μM, respectively) than vindoline.
CiteXplore: 28162858