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ID: ALA3994651
Journal: Bioorg Med Chem Lett
Title: Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor.
Authors: Cheng L, Wu CR, Zhu LH, Li H, Chen LX.
Abstract: Kidney-type glutaminase (KGA) is over expressed in many kinds of cancers that converts glutamine to glutamate for supplying energy, and has become an object for targeted cancer therapy. The structure-based virtual ligand screening identified physapubescin, a withanolide purified from Physalis pubescens L., as a possible inhibitor of KGA with low binding energy. Enzyme inhibition experiments and cell-based assays further confirmed its inhibitory effects on KGA activity, suggesting potential applications of physapubescin and its derivatives as KGA inhibitors.
CiteXplore: 28174105