Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities.
Basic Information
ID: ALA3997838
Journal: Bioorg Med Chem Lett
Title: Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities.
Authors: Yang X, Deng S, Huang M, Wang J, Chen L, Xiong M, Yang J, Zheng S, Ma X, Zhao P, Feng Y.
Abstract: Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2-13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6-9 and 11-13 increased GLUT-4 translocation by the range of 1.35-2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
CiteXplore: 28236591
DOI: 10.1016/j.bmcl.2017.01.078
Patent ID: ┄